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Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD.

Authors
  • 1
Type
Published Article
Journal
Respiratory research
1465-993X
Publication Date
Volume
9
Pages
83–83
Identifiers
DOI: 10.1186/1465-9921-9-83
PMID: 19087346
Source
Medline

Abstract

Fibroblasts of COPD patients and controls differ in their regulation of the Smad pathway, the contrast being most pronounced under CSE exposure. This aberrant responsiveness of COPD fibroblasts to CSE might result in an impaired tissue repair capability and is likely important with regard to the question why only a subset of smokers demonstrates an excess ECM destruction under influence of cigarette smoking.

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