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Expression of 5-HT1Areceptor mRNA in rat nucleus raphe magnus neurons after peripheral inflammation

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
887
Issue
2
Identifiers
DOI: 10.1016/s0006-8993(00)03037-7
Keywords
  • 5-Ht1Areceptor Mrna
  • Carrageenan Inflammation
  • In Situ Hybridization
  • Fluorescent In Situ Hybridization And Immunohistochemistry
  • Nucleus Raphe Magnus

Abstract

Abstract The present study demonstrated that 5-HT 1A receptor mRNA was expressed with moderate level in the NRM neurons. Most of 5-HT 1A receptor mRNA positive cells were 5-HT neurons, suggesting the majority of 5-HT 1A receptor in the NRM might be autoreceptors. Eight hours after carrageenan inflammation, the expression of 5-HT 1A receptor mRNA in the NRM neurons, especially in the 5-HT neurons, was significantly increased. These results suggest that synthesis of 5-HT 1A receptors, including 5-HT 1A autoreceptors, is increased in the NRM during peripheral inflammation.

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