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Effects of 5α-dihydrocorticosterone on evoked responses and long-term potentiation

Authors
Journal
Brain Research Bulletin
0361-9230
Publisher
Elsevier
Publication Date
Volume
19
Issue
6
Identifiers
DOI: 10.1016/0361-9230(87)90049-9
Keywords
  • 5αDihydrocorticosterone
  • Evoked Responses
  • Long-Term Potentiation

Abstract

Abstract The effect of a Ring A-reduced metabolite of corticosterone, 5α-dihydrocorticosterone (DHB) on long-term potentiation (LTP) in the dentate gyrus (DG) of the rat were studied in barbiturate-anaesthetised animals. It was observed that DHB significantly impairs the development of LTP, more particularly the population spike (PS) component of the evoked potential (EP) to perforant path (PP) stimulation. Nutralipid, an inert control solvent of the steroid, did not affect LTP development. We argue that both, membrane and intracellular effects of DHB, are involved in the mechanisms responsible for DHB blocking of LTP.

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