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Chemical and Biotechnological Studies of Hydrolyzable Tannins of Plants of Tamarix Species

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  • Biology
  • Chemistry
  • Medicine

Abstract

氏 名 授 与 した学位 専攻分野の名称 学位記授与番号 学位授与の日付 学位授与の要件 MOHAMEDABDELIMALEKABDALLAHORABI 博士 学術 博甲第4216号 平成22年9月30日 博士の学位論文提出者 (学位規則第5条第1項該当) 学位論文の題目 ChemicalandBiotechnologicalStudiesofHydrolyzableTbmi nsofPlants ofTamarixSpecies(Tamarix種植物の加水分解性タンニンに関する化学 的および生物工学的研究) 論文審査委員 教授 波多野 力 准教授 伊東 秀之 教授 宮地 弘幸 学位論文内容の要旨 Inthefirstpartofthisstudy,chemicalandbiologiCal studiesofhydrolyzabletanninsof tamaricaceousplants,12newellagitaminsincludingeightdiners,nllotiminsDl-D5andD7-D9, andfourmonomers,milotiminsM1-M4,wereisolatedfromanaq.acetoneextractofair-driedleaves ofTniloticacollectedatEgyptInaddition,sevenknownellagitamindimers,hirtellinsA,B,Cand F, isohirtellin C, tami ximin A, milotimin D6, and eight known monomers, I,3-di-0-galloy1-4,6-0-(S)-hexahydroxydiphenoy1-β-D-glucose,remurinsAandB,hippomaminA, geminD,tellimagrandinslandII,and1,2,6ltri-0-galloy1-β-D-glucose,wereisolatedforthefirst timefromthisplantspecies.TheknowndinersnilotininD6andisohirtellinCwereisolatedfroma plantextractforthefirsttime.StructureswereelucidatedbasedonspectroscopICanalysesand chemicalcorrelationswithknowncompounds,Onthebasisoftheresults,reportedspectroscopIC asslgnmentSforhirtellinsAandB,tamariximinAandthemacrocyclictaminshirtellinsCandFand isohirtellinCwererevised.UnusualshiftsintheNMRspectraofthesetanminsarealsodiscussedin relationtotheirconforrnadons・The13cNMRspectroscopicdataforhirtellinsCandF,isohirtellinC, tamariximinA,andremurinsAandBarealsoreportedforthefirsttime. BecausecytotoxicdrugsplayarnaJOrroleincancerchemotherapy,majorT.niloticadiners, hirtellins AandB,andtamarixininA,togetherwithsomerelatedtaming,remurinsAandB, milotininsM4andD8,Withgoodabundanceintheplant,weretestedfortheirpossibledirect cytotoxicactivity onhulnanOralsquamouscellcarcinoma(HSC-2,HSCl3,andHSC-4)and promyelocyticleukemia(HLl60)celllinescomparedwiththeireffectonhumanoralnomalcells (HGF,fIPC,andHPLF).Am ongallofthetestedtami ns,hirtellinAandnilotiminD8showedpotent cytotoxiceffectsandelevatedTSvaluesattheappliedconcentrati

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