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2-Aminopyridine Cadmium (II) meso-chlorophenylporphyrin coordination compound. Photophysical properties, X-ray molecular structure, antimicrobial activity, and molecular docking analysis

Authors
  • Mchiri, Chadlia1
  • Edziri, Hayet2
  • Hajji, Halima3
  • Bouachrine, Mohammed3, 4, 5
  • Acherar, Samir3, 4, 5
  • Frochot, Céline5
  • Eldine, Hanan O Badr6
  • Moussa, Sana Ben6
  • Nasri, Habib1
  • 1 University of Monastir, Avenue de l’Environnement, Monastir, 5019, Tunisia , Monastir (Tunisia)
  • 2 University of Monastir, Monastir, 5019, Tunisia , Monastir (Tunisia)
  • 3 Moulay Ismail University, Meknes, Morocco , Meknes (Morocco)
  • 4 Sultane Moulay Sliman University, Khenifra, Morocco , Khenifra (Morocco)
  • 5 Université de Lorraine, CNRS, 1 rue Grandville BP 20451, Nancy Cedex, 54001, France , Nancy Cedex (France)
  • 6 King Khalid University, Mohail Asser, Saudi Arabia , Mohail Asser (Saudi Arabia)
Type
Published Article
Journal
Journal of Chemical Sciences
Publisher
Springer India
Publication Date
Feb 04, 2022
Volume
134
Issue
1
Identifiers
DOI: 10.1007/s12039-021-02022-0
Source
Springer Nature
Keywords
Disciplines
  • Regular Article
License
Yellow

Abstract

The reaction of the [meso-tetra(p-chlorophenyl)porphyrinato]cadmium(II) complex ([Cd(TClPP)]) with an excess of 2-aminopyridine results in the formation of the corresponding axially ligated (2- aminopyridine)[meso-tetra(p-chlorophenyl)porphyrinato]cadmium(II)with the formula [Cd(TClPP)(2-NH2Py)] (I). This five-coordinated metalloporphyrin was characterized by infrared, UV-visible, fluorescence, singlet oxygen, 1H nuclear magnetic resonance and single crystal X-ray diffraction techniques. The in vitro antimicrobial activity of the freebase porphyrin H2TClPP porphyrin, the [Cd(TClPP)] starting material and complex (I) were screened against different species of bacteria. The assays showed an increase of antimicrobial potential due to the insertion of the cadmium metal into the H2TClPP porphyrin and the axial coordination of 2-aminopyridine. Molecular docking approach indicated that [Cd(TClPP)(2-NH2Py)] has higher binding affinity with hydrogen-bonding interactions.Graphical abstract2-aminopyridine Cadmium(II) meso-chlorophenylporphyrin coordination compound abbreviated as [Cd(TClPP)(2-NH2Py)] was synthesized and characterized. This compound shows interesting antibacterial properties. The molecular docking approach suggests that [Cd(TClPP)(2-NH2Py)] has higher binding affinity with hydrogen bonding interactions.

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