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2-Aminoimidazoles as potent inhibitors of contaminating brewery biofilms.

Authors
  • Jacobs, Lene1
  • Meesters, Jolien1
  • Parijs, Ilse1
  • Hooyberghs, Geert2
  • Van der Eycken, Erik V2, 3
  • Lories, Bram1
  • Steenackers, Hans P1
  • 1 Centrum of Microbial and Plant Genetics, KU Leuven, Belgium. , (Belgium)
  • 2 Laboratory for Organic and Microwave-Assisted Chemistry - LOMAC, KU Leuven, Belgium. , (Belgium)
  • 3 Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Type
Published Article
Journal
Biofouling
Publisher
Informa UK (Taylor & Francis)
Publication Date
Feb 11, 2021
Pages
1–17
Identifiers
DOI: 10.1080/08927014.2021.1874366
PMID: 33573402
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cleaning and disinfection protocols are not always able to remove biofilm microbes present in breweries, indicating that novel anti-biofilm strategies are needed. The preventive activities of three in-house synthesized members of the 2-aminoimidazole class of anti-biofilm molecules were studied against 17 natural brewery biofilms and benchmarked against 18 known inhibitors. Two 2-aminoimidazoles belonged to the top six inhibitors, which were retested against 12 defined brewery biofilm models. For the three best inhibitors, tannic acid (n° 1), 2-aminoimidazole imi-AAC-5 (n° 2), and baicalein (n° 3), the effect on the microbial metabolic activity was evaluated. Here, the top three inhibitors showed similar effectiveness, with baicalein possessing a slightly higher efficacy. Even though the 2-aminoimidazole was the second-best inhibitor, it showed a lower biocidal activity than tannic acid, making it less prone to resistance evolution. Overall, this study supports the potential of 2-aminoimidazoles as a preventive anti-biofilm strategy.

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