Affordable Access

The Embryonic and Postnatal Lethality, Skeletal Abnormalities Are Recognized in Mice with the Disruption of the M33 and mel-18 Mammalian Polycomb Group Genes.

  • ポリコーム遺伝子群
  • ホメオボックス遺伝子群
  • 後方化
  • 相互作用
  • 量的効果
  • Ndc:490
  • Biology


It is known that in Drosophila, Polycomb group (Pc-G) genes are necessary to repress expression of the homeobox genes during the anteroposterior axis patterning. Pc-G gene products make a protein complex, and synergism of the each protein among the complex influences the body patterning strongly. In mammal, the mouse homologue of the Drosophila Pc-G genes have been identified. Recent studies provide the evidence indicating that the mouse homologue of Pc-G gene products are associated in nucleus, and that these mutant mice of the Pc-G gene show homeotic transformation of the axial skeleton as observed in Drosophila Pc-G gene mutants. In order to investigate the functional correlation among mammalian Pc-G genes and the influence of the synergism among the protein complex in vivo, we have generated doubl mutants of the M33 and mel-18 gene. (1) The mutant mice of M33 +/-mel-18-/-, M33-/-mel-18 + /- gene became dead within 3 weeks after birth, but the emphasis of the genetic interaction was not recognized in skeletal abnormalities. (2) The doubl mutants of the M33 and mel-18 gene died in the early stage of embryogenesis. These findings suggest synergism among mammalian Pc-G gene products might play a crucial role not only in regulation of the homeobox gene expression during the anteroposterior axis patterning, but also in survival of individuals.

There are no comments yet on this publication. Be the first to share your thoughts.