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Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals.

Authors
  • 1
Type
Published Article
Journal
Environmental health perspectives
1552-9924
Publication Date
Volume
117
Issue
4
Pages
611–616
Identifiers
DOI: 10.1289/ehp.0800235
PMID: 19440501
Source
Medline
Keywords
  • Blood Vessel
  • Diesel
  • Nitric Oxide
  • Particulate
  • Pollution
  • Superoxide

Abstract

DEP caused oxidative stress through the generation of oxygen-centered free radicals that reduced the bioavailability of endothelium-derived NO without prior interaction with the lung or vascular tissue. These findings provide a mechanism for the adverse cardiovascular effects of particulate air pollution.

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