Affordable Access

Publisher Website

Plasma 17-ketosteroids and 17-beta hydroxysteroids in girls with premature development of sexual hair

Authors
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Publication Date
Volume
79
Issue
2
Identifiers
DOI: 10.1016/s0022-3476(71)80111-7

Abstract

Plasma testosterone and 17-ketosteroids (androstenedione and dehydroepiandrosterone),as well as an index of the unbound testosterone concentration, were assayed in 7 girls with the appearance of sexual hair as an isolated phenomenon. Six had elevation of dehydroepiandrosterone sulfate, accompanied by parallel but slight increases in unbound testosterone into the low adult female range. This pattern of plasma androgens differed from that seen after ACTH stimulation prepubertally and suggests that these children were undergoing premature production of pubertal adrenal 17-ketosteroids. Dexamethasone suppression was undertaken in one child; the results indicated the production of androgens to be ACTH dependent. One child had no detectable abnormality of plasma androgens.

There are no comments yet on this publication. Be the first to share your thoughts.