Abstract We determined the effect on feeding of Lys-D-Pro-Thr (LDPT), an interleukin-1 beta 193–195 analogue which antagonizes the analgesic effects of interleukin-1 beta. Intracerebroventricular administration of 2μg/rat LDPT increased food consumption at the 0–1h time period, although food intake was reduced by LDPT at the 1–2h time period. There was no effect on colonic temperature 1h later. Subcutaneously injected LDPT (2μg/rat) failed to increase food intake for 1h. These data suggest that brain interleukin-1 beta may have a physiological role in feeding suppression.