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Glucose sensing in the low and negative region: utilization of a thin-film electrode

Authors
Journal
Journal of Electroanalytical Chemistry
0022-0728
Publisher
Elsevier
Publication Date
Volume
321
Issue
2
Identifiers
DOI: 10.1016/0022-0728(91)85597-i
Disciplines
  • Biology

Abstract

Abstract Miniature electrodes for an implantable, nonenzyme-based glucose sensor were constructed using thin-film technology. Dc magnetron-sputtered, thin films of platinum deposited on quartz, chromium-presputtered quartz, and titanium-presputtered quartz were evaluated as electrodes in a cyclic voltammetric set-up. Only the latter type of electrode retained its strong adherence to the quartz substrate throughout the testing period. This electrode was evaluated as the working electrode in cyclic voltammetry (CV) from −0.85 V to +0.85 V versus Ag/AgCI. Linear response was observed for a reduction peak near −0.779 V and an oxidation peak near −0.648 V versus a Ag/AgCI electrode at 37°C for glucose concentrations ranging from 50 to 300 mg/dl. There are inflection points of glucose voltammogram. Using these electrodes, the effects of variations of pH, [CO 2], [O 2], glucose concentration, and scan rate on the inflection points of glucose voltammograms were studied. These inflection points, however, seemed to be independent of some of the potential sources of variability.

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