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Interpretation of findings in the cerebrospinal fluid:IV. Syndrome of normality

Journal of Laboratory and Clinical Medicine
Publication Date
  • Clinical And Experimental
  • Biology


Abstract An objective method of selection of 500 “normal” cerebrospinal fluids submitted by mail and the results of their examination by five tests obligatory in the control of neurosyphilis are described. The five examinations and the findings in these normal fluids are as follows: appearance, clear and colorless; complement fixation tests, no reaction; total cell count, 0/3 to 3/3 cells per cubic millimeter; total protein by turbidimetric methods, 16 to 30 mg. per 100 ml; and quantitative colloidal gold reaction, type A curve. The syndrome of normality cannot be established without satisfactory methods of selection of normal cerebrospinal fluids and a quantitative standardized colloidal gold test with which a type A curve is obtained with normal fluid and which is not to be confused with the “negative” gold reaction obtained with unsatisfactory qualitative tests.

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