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A(2A) adenosine receptor binding parameters in platelets from patients affected by pathological gambling.

Authors
  • Martini, Claudia
  • Daniele, Simona
  • Picchetti, Michela
  • Panighini, Anna
  • Carlini, Marina
  • Trincavelli, Maria Letizia
  • Cesari, Daniela
  • Da Pozzo, Eleonora
  • Golia, Francesca
  • Dell'Osso, Liliana
Type
Published Article
Journal
Neuropsychobiology
Publication Date
Jan 01, 2011
Volume
63
Issue
3
Pages
154–159
Identifiers
DOI: 10.1159/000321592
PMID: 21228607
Source
Medline
License
Unknown

Abstract

The elevated A(2A) adenosine receptor binding affinity in platelets from PG patients with respect to control subjects demonstrates for the first time a change in adenosine receptor parameters, and it suggests the involvement of the adenosine system in this pathology. The previously demonstrated hyperactivity of the dopamine system in PG may modulate the A(2A) adenosine receptor, supporting a role for this receptor as a peripheral marker of dopamine dysfunction. Because it is not possible to directly measure the D(2) dopamine receptor in human platelets, these data are particularly relevant to the detection of dopamine dysfunction.

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