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Human Host Factors Required for Influenza Virus Replication

Authors
Journal
Nature
0028-0836
Publisher
Nature Publishing Group
Publication Date
Volume
463
Issue
7282
Identifiers
DOI: 10.1038/nature08699
Keywords
  • Article
Disciplines
  • Biology
  • Engineering

Abstract

Human Host Factors Required for Influenza Virus Replication Renate König1,9, Silke Stertz2,9, Yingyao Zhou3, Atsushi Inoue1, H.-Heinrich Hoffmann2, Suchita Bhattacharyya4, Judith G. Alamares2, Donna M. Tscherne2, Mila B. Ortigoza2, Yuhong Liang2, Qinshan Gao2, Shane E. Andrews6, Sourav Bandyopadhyay5, Paul De Jesus1, Buu P. Tu3, Lars Pache1, Crystal Shih1, Anthony Orth3, Ghislain Bonamy3, Loren Miraglia3, Trey Ideker5, Adolfo García-Sastre2,7,8, John A. T. Young4, Peter Palese2,7, Megan L. Shaw2,10,*, and Sumit K. Chanda1,10,* 1Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA 2Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA 3Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Dr., San Diego, CA 92121, USA 4Nomis Center for Immunobiology and Microbial Pathogenesis The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 5Departments of Medicine and Bioengineering, University of California, San Diego, Pharmaceutical Sciences Bldg, 9500 Gilman Drive, La Jolla, CA 92093, USA 6Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 7Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA 8Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA Influenza A virus is an RNA virus that encodes up to eleven proteins and this small coding capacity demands that the virus utilize the host cellular machinery for many aspects of its life cycle1. Knowledge of these host cell requirements not only informs us of the molecular pathways exploited by the virus but also provides additional targets that could be pursued for antiviral drug development. Here, we employ an integrative sys

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