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Synthesis and biological evaluation of unnatural canthine alkaloids

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
46
Issue
16
Identifiers
DOI: 10.1016/j.tetlet.2005.02.143
Disciplines
  • Biology

Abstract

Abstract Employing a ‘one-pot’ microwave-assisted protocol, unnatural canthine alkaloids with biological activities beyond the natural products have been prepared. This report describes unnatural canthine alkaloid analogs as selective, allosteric Akt kinase inhibitors.

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