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Convenient preparation of optically pure propargylic alcohols using 2-(trimethylsilyl)vinyl sulfoxide as a novel chiral synthon

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
34
Issue
41
Identifiers
DOI: 10.1016/0040-4039(93)88112-v

Abstract

Abstract Both enantiomers of optically pure propargylic alcohols are conveniently prepared by the reaction of α-vinyl anion of 2-(trimethylsilyl)vinyl p-tolyl sulfoxide with aldehydes and subsequent either desilylsulfinylation or thermal elimination of the sulfinyl group.

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