Affordable Access

Publisher Website

Quality and quantity control at the endoplasmic reticulum

Authors
Journal
Current Opinion in Cell Biology
0955-0674
Publisher
Elsevier
Publication Date
Volume
22
Issue
4
Identifiers
DOI: 10.1016/j.ceb.2010.05.005
Disciplines
  • Biology
  • Medicine

Abstract

The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins that together make up about one third of the cellular proteome. Cells carefully control the synthetic output of this organelle to regulate both quality and quantity of proteins that emerge. Here, we synthesize current concepts underlying the pathways that mediate protein degradation from the ER and their deployment under physiologic and pathologic conditions.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Quality control in the endoplasmic reticulum.

on Seminars in Cell and Developme... July 2010

Quality control in the endoplasmic reticulum.

on Nature Reviews Molecular Cell... March 2003

Quantity control of the ErbB3 receptor tyrosine ki...

on Molecular and Cellular Biology July 2011
More articles like this..