Abstract Based upon the assessement of anxiety/depression and functional heart symptoms in high risk (HRS) and low risk samples (LRS) participating in clinical trials, the present study concluded that screening and intervention did not have psychological costs to the randomized sample (HRS). The results of the present study were compared to parallel studies in other clinical trials. The main conclusion was that the HRS group had less depressive symptoms than the group (LRS) that did not enter the trial. The psychological reactions to screening and intervention programs may have person-environment interactions that lead to different outcomes based upon the specific population under study. The present paper attempts to integrate the findings in the previous studies.