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Antidepressant-like effect of centrally acting non-narcotic antitussive caramiphen in a forced swimming test

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
481
Issue
3
Identifiers
DOI: 10.1016/j.neulet.2010.07.003
Keywords
  • Antitussives
  • Antidepressant-Like Effect
  • Caramiphen
  • Forced Swimming Test
  • G-Protein-Coupled Inwardly Rectifying K+ (Girk) Channel
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract Recently, we reported that a centrally acting non-narcotic antitussive (cough suppressant drug), tipepidine produces an antidepressant-like effect in the forced swimming test in rats. Because pharmacological properties of tipepidine apparently differ from those of typical antidepressants developed to date, we speculated that caramiphen, another centrally acting antitussive, has an antidepressant-like effect. That effect of caramiphen was studied in rats using the forced swimming test. Caramiphen at 20 and 40 mg/kg i.p. significantly reduced immobility. At 40 mg/kg i.p., it increased climbing behavior. Even at 40 mg/kg, this drug had no effect on locomotor activity. Results suggest that a centrally acting antitussive possessing inhibition of GIRK channels has an antidepressant-like effect.

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