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Mupirocin resistance is not an inevitable consequence of mupirocin use

Authors
Journal
Journal of Hospital Infection
0195-6701
Publisher
Elsevier
Publication Date
Volume
79
Issue
4
Identifiers
DOI: 10.1016/j.jhin.2011.08.009
Keywords
  • Genotyping
  • Meticillin-Resistantstaphylococcus Aureus
  • Mupirocin
  • Resistance

Abstract

Summary The rate of mupirocin resistance in meticillin-resistant Staphylococcus aureus (MRSA) in Besançon University Hospital is low with a decreasing trend, from 10% in 2004 to 3% in 2009. This trend in resistance paralleled mupirocin consumption. Genotyping results showed that this decrease was not linked to a change in MRSA clones. It appears that the way in which the mupirocin is used, rather than the volume, plays a role in the emergence of resistance and that its cautious use is likely to maintain the mupirocin resistance at a low level, thus preserving its efficacy.

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