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Capacitative calcium entry : sensing the calcium stores

Authors
Journal
The Journal of Cell Biology
0021-9525
Publisher
The Rockefeller University Press
Publication Date
Volume
169
Issue
3
Identifiers
DOI: 10.1083/jcb.200503161
Keywords
  • Reviews
  • Comment
Disciplines
  • Biology

Abstract

A long-standing mystery in the cell biology of calcium channel regulation is the nature of the signal linking intracellular calcium stores to plasma membrane capacitative calcium entry channels. An RNAi-based screen of selected Drosophila genes has revealed that a calcium-binding protein, stromal interaction molecule (STIM), plays an essential role in the activation of these channels and may be the long sought sensor of calcium store content.

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