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Studies on the Electrical Potentials of Living Organisms: III. Effects of Elevated Body Temperatures in Normal Unanesthetized Mice *

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STUDIES ON THE ELECTRICAL POTENTIALS OF LIVING ORGANISMS: III. EFFECTS OF ELEVATED BODY TEMPERATURES IN NORMAL UNANESTHETIZED MICE.* CLYDE MARSHALL AND RALPH G. MEADER In a preceding paper we reported the effects of a lowered body temperature on the electrical potentials of male mice. The present contribution offers the results obtained from elevating the body temperature of a similar group of mice. A continuous electrical record of unanesthetized mice during base-line conditions followed by a period of elevated temperature was secured by the same method as described in the previous report, namely, by use of the Burr, Lane, Nims microvoltmeter operating a General Electric photo-electric recording galvanometer. The rise of temperature was secured by placing the animals in a chamber, the air of which was saturated with water vapor and heated by electric lamps. A glass window in the chamber permitted observation of the animal while the experiment was in progress. The glass tubes containing the salt bridges passed through small holes in the walls of the chamber so that the elec- trodes themselves remained outside of the box and were not heated. A thermocouple inserted in the mouse's rectum was connected with another photo-electric recording galvanometer outside the box. Twenty-one male mice from the colony of Dr. L. C. Strong were available. They were of the CBA strain previously used and were selected because animals in this group showed certain changes in electrical potentials associated with chilling. They ranged in age from 192 to 250 days, which means that they were all within the first third of the life span. These animals were somewhat older than those used for the chilling experiment, but no difference could be determined between the initial potentials of these and of younger mice in our previous study. The electrical potentials were determined for 30 minutes prior to heating the animals. The values at 5-minute intervals were * From the Laboratory of Neuro-Anatomy, Yale University Scho

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