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Surgical management of retroperitoneal sarcomas associated with external and intraoperative electron beam radiotherapy

Authors
Journal
European Journal of Surgical Oncology (EJSO)
0748-7983
Publisher
Elsevier
Publication Date
Volume
29
Issue
8
Identifiers
DOI: 10.1016/s0748-7983(03)00139-2
Keywords
  • Retroperitoneal Sarcomas
  • Surgery
  • Intraoperative Radiotherapy
Disciplines
  • Medicine

Abstract

Abstract Aims: To report outcomes of adults with retroperitoneal sarcoma (RS) treated by surgery, external beam radiotherapy (EBRT) and intraoperative electron beam radiotherapy (IORT). Methods: From July 1988 to February 2001; 24 patients with primary and recurrent RS were diagnosed and treated. The median dose and energy of IORT delivered was 15 Gy/9 meV. EBRT dose varies between 45–50 Gy. Results: There were five primary and 19 recurrent tumours. One primary and five recurrent tumours underwent R0 resection. There were 12 liposarcomas and 19 grade I tumours; 13 patients developed local recurrence and three developed distant metastases. Twenty-two patients received IORT associated with EBRT: 11 developed recurrences. Six patients developed Neurotoxicity (4 grade II and 2 grade III). Disease free survival and overall survival at 5 years was 28 and 56% respectively. Conclusions: EBRT with IORT treatment is a promising technique for local control. Lower recurrence rates are associated with radical (R0) surgical procedures.

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