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Another Facet of Ubiquitylation: Death

Authors
Publisher
Oxford University Press
Publication Date
Source
Legacy
Keywords
  • Institute Of Experimental Immunology
  • 570 Life Sciences
  • Biology
  • 610 Medicine & Health

Abstract

Ubiquitylation of caspase-8 by the Cullin3 E3 ligase allows its translocation to cytosolic aggregates in the cell by p62/sequesto- some-1, increasing caspase-8 activation and thus leading to TRAIL-induced cell death.

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