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Chemical analysis of Agaricus blazei polysaccharides and effect of the polysaccharides on IL-1β mRNA expression in skin of burn wound-treated rats

Authors
Journal
International Journal of Biological Macromolecules
0141-8130
Publisher
Elsevier
Publication Date
Volume
47
Issue
2
Identifiers
DOI: 10.1016/j.ijbiomac.2010.05.006
Keywords
  • Rat
  • Agaricus Blazei Polysaccharides
  • Gc–Ms
  • Skin
  • Il-1β

Abstract

Abstract Agaricus blazei polysaccharides were analyzed by GC–MS. Results indicated that the polysaccharides contained glucose (93.87%), mannose (3.54%), and arabinose (2.25%). The compositional analysis was completed by the methylation data. These data indicated that Agaricus blazei polysaccharides are glucans. Compared to model rats, rats fed with Agaricus blazei polysaccharides showed a decrease of ratio of IL-1β/β-actin and IL-1β level in skin of burn wound. Recovery rate of wound skin increased with increasing dose of polysaccharides. The results indicated that Agaricus blazei polysaccharides could be useful in promote burn wound healing.

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