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Morphology and properties of poly vinyl alcohol (PVA) scaffolds: Impact of process variables

Authors
Journal
Materials Science and Engineering C
0928-4931
Publisher
Elsevier
Volume
42
Identifiers
DOI: 10.1016/j.msec.2014.05.029
Keywords
  • Pva Scaffold
  • Foaming
  • Surfactant
  • Freeze Drying
  • Interconnected Micro-Pores
Disciplines
  • Biology
  • Engineering

Abstract

Abstract Successful engineering of functional biological substitutes requires scaffolds with three-dimensional interconnected porous structure, controllable rate of biodegradation, and ideal mechanical strength. In this study, we report the development and characterization of micro-porous PVA scaffolds fabricated by freeze drying method. The impact of molecular weight of PVA, surfactant concentration, foaming time, and stirring speed on pore characteristics, mechanical properties, swelling ratio, and rate of degradation of the scaffolds was characterized. Results show that a foaming time of 60s, a stirring speed of 1000rpm, and a surfactant concentration of 5% yielded scaffolds with rigid structure but with interconnected pores. Study also demonstrated that increased foaming time increased porosity and swelling ratio and reduced the rigidity of the samples.

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