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Antibiofilm Efficacy of DispersinB® Wound Spray Used in Combination with a Silver Wound Dressing

Authors
Publisher
Libertas Academica
Publication Date
Keywords
  • Microbiology Insights
  • Volume: 2014
  • Issue: 7
Disciplines
  • Biology
  • Medicine
  • Philosophy

Abstract

9Microbiology insights 2014:7 Open Access: Full open access to this and thousands of other papers at http://www.la-press.com. Microbiology Insights Antibiofilm Efficacy of DispersinB® Wound Spray Used in Combination with a Silver Wound Dressing Purushottam V. gawande1, Allie P. clinton2, Karen loVetri1, nandadeva yakandawala1, Kendra P. rumbaugh2 and srinivasa Madhyastha1 1Kane Biotech Inc., Winnipeg, MB, Canada. 2Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, USA. ABSTRACT: Chronic wounds including diabetic foot ulcers, pressure ulcers, and venous leg ulcers are a worldwide health problem. As the traditional methods of treatment have proven ineffective against chronic wounds involving biofilms, there is an unmet clinical need for developing products with an antibiofilm component that inhibits and/or disrupts biofilms and thus make the biofilm-embedded bacteria more susceptible to antimicrobial therapy. We developed a DispersinB® antibiofilm enzyme-based wound spray for treating chronic wounds in conjunction with an antimicrobial. Under in vitro condi- tions, the DispersinB® and Acticoat™ combination performed significantly better (P  0.05) than Acticoat™ alone, indicating the synergy between the two compounds because of DispersinB® enhancing the antimicrobial activity of Acticoat™. Furthermore, DispersinB® wound spray enhanced the antimicro- bial activity of Acticoat™ in a chronic wound mouse model of methicillin-resistant Staphylococcus aureus (MRSA) infection. Thus, this novel combination of DispersinB® and Acticoat™, an antimicrobial dressing, prompts clinical evaluation for potential applications in biofilm-based chronic wound management. KEY WORDS: biofilm, DispersinB®, chronic wound, MRSA, silver CITATION: Gawande et al. Antibiofilm Efficacy of DispersinB® Wound Spray Used in Combination with a Silver Wound Dressing. Microbiology Insights 2014:7 9–13 doi:10.4137/Mbi.s13914. RECEIVED: December 16, 2013. RESUBMITTED: January

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