Affordable Access

Publisher Website

Pulsed Focused Ultrasound Treatment of Muscle Mitigates Paralysis-Induced Bone Loss in the Adjacent Bone: A Study in a Mouse Model

Authors
Journal
Ultrasound in Medicine & Biology
0301-5629
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.ultrasmedbio.2014.02.027
Keywords
  • Pulsed Focused Ultrasound
  • Paralysis
  • Mitigation Of Trabecular Bone Loss
  • Mouse Model Of Disuse
  • Musculoskeletal
  • Micro-Computed Tomography
Disciplines
  • Medicine
  • Pharmacology

Abstract

Abstract Bone loss can result from bed rest, space flight, spinal cord injury or age-related hormonal changes. Current bone loss mitigation techniques include pharmaceutical interventions, exercise, pulsed ultrasound targeted to bone and whole body vibration. In this study, we attempted to mitigate paralysis-induced bone loss by applying focused ultrasound to the midbelly of a paralyzed muscle. We employed a mouse model of disuse that uses onabotulinumtoxinA-induced paralysis, which causes rapid bone loss in 5 d. A focused 2 MHz transducer applied pulsed exposures with pulse repetition frequency mimicking that of motor neuron firing during walking (80 Hz), standing (20 Hz), or the standard pulsed ultrasound frequency used in fracture healing (1 kHz). Exposures were applied daily to calf muscle for 4 consecutive d. Trabecular bone changes were characterized using micro-computed tomography. Our results indicated that application of certain focused pulsed ultrasound parameters was able to mitigate some of the paralysis-induced bone loss.

There are no comments yet on this publication. Be the first to share your thoughts.