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A novel antiganglioside specificity against terminal NeuNAc(alfa 2–3)Gal in acute bulbar palsy

Authors
Journal
Journal of Neuroimmunology
0165-5728
Publisher
Elsevier
Publication Date
Volume
176
Identifiers
DOI: 10.1016/j.jneuroim.2006.04.001
Keywords
  • Antiganglioside Antibodies
  • Acute Bulbar Palsy
  • Gm3
  • Gd1A
  • Gt1B
Disciplines
  • Biology
  • Medicine

Abstract

Abstract We describe a patient with acute oropharyngeal–facial diplegia, tongue palsy and albuminocytological dissociation following upper respiratory tract infection. Electrophysiological abnormalities in blink reflex suggested a brainstem lesion. High titers of anti-GM3, GD1a and GT1b IgG class serum antibodies were initially detected. Absorption studies indicated that antibodies were directed to a common terminal epitope NeuNAc(alfa 2–3)Gal. This novel antiganglioside antibody specificity may play a role in this unusual regional form of acute bulbar palsy of possible central origin. These data are supportive for extending the panel of antiganglioside specificities with anti-GM3.

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