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Biogenic amines and acute thermal stress in the rat

Authors
Journal
Comparative Biochemistry and Physiology Part C Comparative Pharmacology
0306-4492
Publisher
Elsevier
Publication Date
Volume
51
Issue
1
Identifiers
DOI: 10.1016/0306-4492(75)90040-4
Keywords
  • Heat Stress
  • Cold Stress
  • Parachlorophenylalanine
  • Pcpa
  • Dl-α-Methyl-P-Tyrosine
  • Serotonin
  • 5-Ht
  • Norepinephrine
  • Biogenic Amines
  • Reserpine
  • Rectal Temperature
  • Amt
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract 1. 1. Rats pretreated with biogenic-amine depleting agents demonstrated significant alterations in rectal temperatures ( T re) in response to 1 hr of acute thermal stress. 2. 2. Depletion of norepinephrine (NE) caused a significant depression of equilibrium T re at 22°C and a greater depression of T re than controls in response to cold (6°C) stress. NE depletion also caused a significantly higher T re response to an acute heat (38°C) stress. 3. 3. Animals in which 5-hydroxytryptamine (5-HT) was depleted showed no significant difference in equilibrium T re at 22°C, and no significant difference in T re during cold stress, but a lesser rise in T re in the heat stress when compared to control animals. 4. 4. Simultaneous depletion of NE and 5-HT caused thermoregulatory responses et equilibrium and at 38°C similar to those produced by depletion of NE. 5. 5. It appears that normal thermoregulation during acute temperature stress may be disrupted by pharmacologic agents which deplete NE and 5-HT but it is still unclear whether the primary site of action of these agents is central or peripheral.

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