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Preparation of opium alkaloids by palladium catalyzed bis-cyclizations. Formal total synthesis of morphine

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
35
Issue
21
Identifiers
DOI: 10.1016/s0040-4039(00)73208-4

Abstract

Abstract Palladium catalyzed cyclization of hydroisoquinoline diene 10 to afford the pentacyclic opiate 11 is the central step in a new synthesis of opium alkaloids.

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