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Referral of Queensland women with endometrial cancer to genetic services

Authors
Publisher
BioMed Central
Publication Date
Volume
10
Identifiers
DOI: 10.1186/1897-4287-10-s2-a63
Keywords
  • Meeting Abstract
Disciplines
  • Medicine

Abstract

MEETING ABSTRACT Open Access Referral of Queensland women with endometrial cancer to genetic services YY Tan1,2*, J McGaughran3, A Obermair1,2, A Spurdle4 From Familial Aspects of Cancer 2011 Research and Practice: A combined meeting of kConFab, Australian Breast Cancer Family Study, Australian Colorectal Cancer Family Study, Australian Ovarian Cancer Study, Family Cancer Clinics of Australia and New Zealand and kConFab Kingscliff, Australia. 23-26 August 2011 Approximately 5% of all endometrial cancers are due to a hereditary disposition, and a majority of the cases were found in families with Lynch syndrome or heredi- tary non-polyposis colorectal cancer (HNPCC) syn- drome. Whilst both men and women with Lynch syndrome have a significantly increased risk of develop- ing colorectal cancer (18-69%), women face the addi- tional lifetime risks of developing endometrial cancer – between 27% to 71% as compared to 2% in the Austra- lian general population. Despite the increased risk, many eligible women who may benefit from genetic assess- ment are not being referred by their treating clinician. The purpose of this study is to evaluate the patterns of referral of women diagnosed with endometrial cancer to genetic services. Using the diagnostic, clinical and refer- ral databases from three different sites, we were able to link data of endometrial cancer cases in Queensland from May 2005 to December 2007. We determined the percentage of women diagnosed with endometrial can- cer who could have been referred based on at least one risk factor suggestive of Lynch syndrome, the percentage of women that were referred and the percentage of women that attended genetic services. The revised Amsterdam and Bethesda criteria guidelines were adapted and used to assess the appropriateness of refer- ral. Preliminary results show that of the 955 new diag- nosis of endometrial cancer, 29 women (3%) were referred and 17 (1.8%) attended. This suggests that women who may benefit from genetic assessment do not ulti

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