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Quantitative structure-activity relationships of cysteine hydrolases. Ficin hydrolysis of X-phenyl-N-methanesulfonyl glycinates

Authors
Journal
Chemico-Biological Interactions
0009-2797
Publisher
Elsevier
Publication Date
Volume
52
Issue
3
Identifiers
DOI: 10.1016/0009-2797(85)90023-7
Keywords
  • Ficin
  • Quantitative Structure-Activity Relationship
  • Cysteine Proteinases
  • N-Methanesulfonylphenyl Glycinates

Abstract

Abstract The hydrolysis by ficin of 33 X-Phenyl- N-methanesulfonyl glycinates has been studied. The resulting K m-values have been used to derive a quantitative structure-activity relationship (QSAR). The QSAR for ficin is compared with QSAR for other cysteine hydrolases. The comparisons show that although there are specific differences, overall the reaction mechanisms are very similar.

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