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2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations

Authors
  • Trzaska, Carole1
  • Amand, Séverine2
  • Bailly, Christine2
  • Leroy, Catherine1
  • Marchand, Virginie3
  • Duvernois-Berthet, Evelyne4
  • Saliou, Jean-Michel5
  • Benhabiles, Hana1
  • Werkmeister, Elisabeth6
  • Chassat, Thierry7
  • Guilbert, Romain7
  • Hannebique, David7
  • Mouray, Anthony7
  • Copin, Marie-Christine1
  • Moreau, Pierre-Arthur8
  • Adriaenssens, Eric9
  • Kulozik, Andreas10
  • Westhof, Eric11
  • Tulasne, David1
  • Motorin, Yuri12
  • And 2 more
  • 1 CANTHER – Cancer Heterogeneity, Plasticity and Resistance to Therapies, Lille, 59000, France , Lille (France)
  • 2 UMR 7245 CNRS-MNHN, Paris, 75005, France , Paris (France)
  • 3 UMS2008 IBSLor CNRS-Université de Lorraine-INSERM, BioPôle, Vandoeuvre-les-Nancy, 54505, France , Vandoeuvre-les-Nancy (France)
  • 4 UMR7221 CNRS-MNHN, Paris, 75005, France , Paris (France)
  • 5 University of Lille, Lille, 59000, France , Lille (France)
  • 6 Cellular Microbiology and Physics of Infection Group, Center for Infection and Immunity of Lille, CNRS UMR8204, INSERM U1019, Institut Pasteur de Lille, Lille Regional Univ. Hosp. Centr., Lille Univ., Lille, 59000, France , Lille (France)
  • 7 Institut Pasteur de Lille – PLEHTA (Plateforme d’expérimentation et de Haute Technologie Animale), Lille, 59019, France , Lille (France)
  • 8 LGCgE, Laboratoire de Génie Civil et géo-Environnement, Lille, 59000, France , Lille (France)
  • 9 CANTHER – Cancer Heterogeneity, Plasticity and Résistance to Therapies, Lille, 59000, France , Lille (France)
  • 10 EMBL/Medical Faculty Molecular Medicine Partnership Unit, Heidelberg, 69120, Germany , Heidelberg (Germany)
  • 11 Institute of Molecular and Cellular Biology of the CNRS UPR9002/University of Strasbourg, Strasbourg, 67084, France , Strasbourg (France)
  • 12 CNRS - Université de Lorraine, Vandoeuvre-les-Nancy, 54505, France , Vandoeuvre-les-Nancy (France)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Mar 20, 2020
Volume
11
Issue
1
Identifiers
DOI: 10.1038/s41467-020-15140-z
Source
Springer Nature
License
Green

Abstract

Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity.

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