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Solid phase sequential 1,3-dipolar cycloaddition–Pictet–Spengler reactions

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
41
Issue
6
Identifiers
DOI: 10.1016/s0040-4039(99)02183-8
Keywords
  • Cycloaddition
  • Pictet–Spengler Reaction
  • Pd Catalysis
  • Cascade Reaction

Abstract

Abstract Up to six bonds and two rings can be created, in five component processes (five points of diversity), by AgOAc catalysed imine cycloaddition to Wang resin acrylate followed by Pictet–Spengler and Pd(0) catalysed reactions.

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