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1985 — the year of the hypertension trials: interpreting the results

Authors
Journal
Trends in Pharmacological Sciences
0165-6147
Publisher
Elsevier
Publication Date
Volume
7
Identifiers
DOI: 10.1016/0165-6147(86)90290-7
Disciplines
  • Medicine

Abstract

Abstract Increasing numbers of patients with elevated blood pressure are currently receiving antihypertensive drugs on the basis that evidence has accumulatedfor the benefits of therapy in moderate and severe hypertension (diastolic blood pressure > 105 mm Hg, phase V) 1,2. Many clinicians have logically assumed that effectiveness of treatment can be extraoplarated to patients with mild hypertension (diastolic blood pressure 90–109 mm Hg). However, Peter Sever emphasizes this is not necessarily the case and comments that the individual risk to patients with mild hypertension is small and large numbers would have to be treated in order to demonstrate a reduction in total population risk from cardiovascular morbidity and mortality — if indeed antihypertensive drugs in this group of individuals proved beneficial.

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