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Stimulation of natural host defence mechanisms in rodents by nesosteine

Authors
Journal
International Journal of Immunopharmacology
0192-0561
Publisher
Elsevier
Publication Date
Volume
10
Issue
1
Identifiers
DOI: 10.1016/0192-0561(88)90151-8
Disciplines
  • Medicine

Abstract

Abstract The effect of Nesosteine, a novel mucolytic agent, on natural host resistance mechanisms was investigated in different organs of mice and rats. Single or repeated administrations of nesosteine by the i.v. or oral route ( per os) were associated with significant increases in lung and spleen NK-mediated cytotoxicity, and in alveolar and peritoneal macrophages direct cytotoxocity. In both species the dose - response curve was bell-shaped, and optimal activity on both parameters seen at 1 mg/kg i.v. × 1, 100 mg/kg per os × 1 or 20 mg/kg per os × 5. Increases of at least 100% in lung NK and alveolar macrophages cytotoxicity were found in mice 48 h after single oral dosing at 100 mg/kg. The possible importance of Nesosteine immunostimulatory capacity in the activity of this compound in chronic hypersecretive bronchopulmonary disorders is discussed.

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