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Estrous cycle modification of rat uterine DNA alkylation byN-methyl-N-nitrosourea

Authors
Journal
Cancer Letters
0304-3835
Publisher
Elsevier
Publication Date
Volume
37
Issue
3
Identifiers
DOI: 10.1016/0304-3835(87)90120-0
Disciplines
  • Design

Abstract

Abstract The present study was designed to determine whether the stage of the estrous cycle at the time of N-nitroso- N-methylurea (NMU) presentation altered DNA adduct formation and repair in the rat uterus. In uterus the rate of O 6-methylguanine (O 6-meGua) and 7-methylguanine (7-meGua) formation and the total yield of adducts was estrous cycle dependent. Uterine DNA from rats injected with NMU on diestrus formed O 6-meGua and 7-meGua more rapidly and had significantly higher adduct levels than those rats injected on proestrus or estrus. Repair of O 6-meGua and 7-meGua was also significantly faster between 1 and 24 h post-NMU in uterine DNA isolated from rats injected on diestrus compared to those injected on proestrus or estrus.

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