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Dynamic kinetic resolution of racemicN-phthalyl amino acids using (S)-α-methylpantolactone as the chiral auxiliary

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
11
Issue
3
Identifiers
DOI: 10.1016/s0957-4166(00)00017-3

Abstract

Abstract A dynamic kinetic resolution of racemic N-phthalyl amino acids by stereoselective esterification was examined using ( S)-α-methylpantolactone as the chiral auxiliary. The reaction of various racemic N-phthalyl amino acids with this chiral alcohol in the presence of both DCC and DMAP afforded predominantly the ( S, S)-esters in nearly quantitative yield.

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