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Alterations of renal phenotype and gene expression profiles due to protein overload in NOD-related mouse strains

Authors
Publisher
BioMed Central
Publication Date
Source
PMC
Keywords
  • Research Article
Disciplines
  • Biology
  • Medicine

Abstract

1471-2369-6-17.fm ral ss BioMed CentBMC Nephrology Open AcceResearch article Alterations of renal phenotype and gene expression profiles due to protein overload in NOD-related mouse strains Karen HS Wilson1,5, Richard A McIndoe1, Sarah Eckenrode1, Laurence Morel2, Anupam Agarwal4, Byron P Croker*2,3 and Jin-Xiong She*1 Address: 1Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, PV6B108, Augusta, GA 30912-2400, USA, 2Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA, 3North Florida/South Georgia Veterans Health System, Gainesville, FL 32608, USA, 4MD Division of Nephrology, ZRB 614, University of Alabama at Birmingham, 1530 3rd Avenue South Birmingham, AL 35294, USA and 5The Royal Swedish Academy of Sciences, Kristinebergs Marina Forksningsstation, Fiskebackskil, SE-45034, Sweden Email: Karen HS Wilson - [email protected]; Richard A McIndoe - [email protected]; Sarah Eckenrode - [email protected]; Laurence Morel - [email protected]; Anupam Agarwal - [email protected]; Byron P Croker* - [email protected]; Jin-Xiong She* - [email protected] * Corresponding authors Abstract Background: Despite multiple causes, Chronic Kidney Disease is commonly associated with proteinuria. A previous study on Non Obese Diabetic mice (NOD), which spontaneously develop type 1 diabetes, described histological and gene expression changes incurred by diabetes in the kidney. Because proteinuria is coincident to diabetes, the effects of proteinuria are difficult to distinguish from those of other factors such as hyperglycemia. Proteinuria can nevertheless be induced in mice by peritoneal injection of Bovine Serum Albumin (BSA). To gain more information on the specific effects of proteinuria, this study addresses renal changes in diabetes resistant NOD-related mouse strains (NON and NOD.B10) that were made to develop proteinuria by BSA overload. Methods: Proteinuri

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