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The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle

Authors
Journal
British Journal of Cancer
0007-0920
Publisher
Nature Publishing Group
Publication Date
Keywords
  • Articles

Abstract

Sprague-Dawley rats aged 50 days were given single oral doses of the carcinogen, DMBA. Rats receiving the carcinogen at the same stage of the oestrous cycle were grouped together and mammary tumour production was compared between these groups. When the carcinogen was given during di-oestrus the mean number of tumours per animal was significantly greater than when it was given at other stages in the oestrous cycle. There was considerable variation in total tumour yield from one batch of animals to another.

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