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The discovery that xeroderma pigmentosum (XP) results from defective nucleotide excision repair

Authors
Journal
DNA Repair
1568-7864
Publisher
Elsevier
Publication Date
Volume
3
Issue
2
Identifiers
DOI: 10.1016/j.dnarep.2003.10.007
Keywords
  • Xeroderma Pigmentosum
  • History
  • Dna Repair
  • Hereditary Diseases
Disciplines
  • Medicine

Abstract

Abstract Most forms of the human hereditary disease xeroderma pigmentosum (XP) are due to a defect in nucleotide excision repair of DNA damage in skin cells associated with exposure to sunlight. This discovery by James Cleaver had an important impact on our understanding of nucleotide excision repair in mammals.

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