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Teratogenic compounds ofVeratrum californicum(Durand) VII. The structure of the glycosidic alkaloid cycloposine

Authors
Journal
Steroids
0039-128X
Publisher
Elsevier
Publication Date
Volume
13
Issue
5
Identifiers
DOI: 10.1016/s0039-128x(69)80012-7

Abstract

Abstract The structure was elucidated of a polar, glycosidic alkaloid, cycloposine, from Veratrum californicum, known to produce fetal cyclopia and related central nervous system malformations in sheep. Data from I.R., N.M.R., mass spectrometry and other means identified the structure as 3-glucosylcyclopamine. Thus, it is the glycoside of another teratogenic alkaloid, cyclopamine (11-deoxojervine) and hence 3-glucosyl-11-deoxojervine.

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