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  • The Yin And Yang Of Immune Privilege In The Eye
  • The Eye And The Brain Are Prototypical Tissues Manifesting Immune Privilege (Ip) In Which Immune Res
  • Particularly Alloantigens Are Suppressed
  • And Even Completely Inhibited
  • Explanations For This Phenomenon Are Numerous And Mostly Reflect Our Evolving Understanding Of The M
  • Ip Is Now Viewed As A Property Of Many Tissues And The Level Of Expression Of Ip Varies Not Only Wit
  • As A Result
  • Ip Functions Normally As A Homeostatic Mechanism Preserving Normal Function In Tissues
  • Particularly Those With Highly Specialized Function And Limited Capacity For Renewal Such As The Eye
  • However
  • Ip Is Relatively Easily Bypassed In The Face Of A Sufficiently Strong Immunological Response
  • And The Privileged Tissues May Be At Greater Risk Of Collateral Damage Because Its Natural Defenses
  • This Two-Edged Sword Cuts Its Swathe Through The Eye: Under Most Circumstances
  • Ip Mechanisms Such As Blood-Ocular Barriers
  • Intraocular Immune Modulators
  • Induction Of T Regulatory Cells
  • Lack Of Lymphatics
  • And Other Properties Maintain Tissue Integrity
  • However
  • When These Are Breached
  • Various Degrees Of Tissue Damage Occur From Severe Tissue Destruction In Retinal Viral Infections An
  • To Less Severe Inflammatory Responses In Conditions Such As Macular Degeneration
  • Conversely
  • Ocular Ip And Tumor-Related Ip Can Combine To Permit Extensive Tumor Growth And Increased Risk Of Me


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