Arguably, job designs that provide for high levels of employee control also provide increased opportunities for the development and exercise of skill. Perceived skill utilization has consistently been found to be amongst the strongest predictors of job-related affective well-being, yet is frequently neglected in studies of work redesign. In this article, a theoretical framework linking the key job characteristics of perceived control and perceived cognitive demand to perceived skill utilization and intrinsic job satisfaction is presented. Results from one cross-sectional study and one longitudinal study are reported that support the mediational influence of perceived skill utilization on the perceived job control – job satisfaction relationship only. The relationship between perceived job demand and perceived skill utilization was mixed but no mediating effect was evident. It is argued that the level of both perceived demand and perceived control dictates the nature of the joint influence of both job characteristics on perceived skill utilization and work attitudes such as job satisfaction.