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Induction of DNA synthesis by dichloroisoproterenol without initial rise of the cAMP level in the parotid gland of mouse

Authors
Journal
Experimental Cell Research
0014-4827
Publisher
Elsevier
Publication Date
Volume
94
Issue
2
Identifiers
DOI: 10.1016/0014-4827(75)90509-1

Abstract

Abstract The increase in the cAMP concentration in the parotid gland of mouse, observed shortly after administration of isoproterenol, was not detected after dichloroisoproterenol, a β-adrenergic blocking agent. The latter compound, however, could induce DNA synthesis which was comparable to that induced by IPR in several respects. The results strongly suggest that the initial rise of cAMP concentration in the parotid gland after IPR injection is not related directly to the initiation of the stimulated DNA synthesis.

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