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Amniotic-fluid ingestion enhances the central analgesic effect of morphine

Authors
Journal
Brain Research Bulletin
0361-9230
Publisher
Elsevier
Publication Date
Volume
26
Issue
6
Identifiers
DOI: 10.1016/0361-9230(91)90248-i
Keywords
  • Poef
  • Analgesia
  • Pain
  • Rats
  • Morphine
  • Opioids
  • Placenta
  • Quaternary Naltrexone
  • Amniotic Fluid
  • Placentophagia
  • Naltrexone Methobromide

Abstract

Abstract Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine.

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