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Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival.

Authors
  • 1
Type
Published Article
Journal
Breast cancer research : BCR
1465-542X
Publication Date
Volume
11
Issue
6
Identifiers
DOI: 10.1186/bcr2448
PMID: 19903352
Source
Medline

Abstract

Our data constitutes the first report of direct involvement of 5-HT in human breast cancer. Increased 5-HT biosynthetic capacity accompanied by multiple changes in 5-HT receptor expression and signaling favor malignant progression of human breast cancer cells (for example, stimulated proliferation, inappropriate cell survival). This occurs through uncoupling of serotonin from the homeostatic regulatory mechanisms of the normal mammary epithelium. The findings open a new avenue for identification of diagnostic and prognostic markers, and valuable new therapeutic targets for managing breast cancer.

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