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Isolation and characterization of human blood platelet gelsolin

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
174
Issue
1
Identifiers
DOI: 10.1016/0014-5793(84)81082-0
Keywords
  • Blood Platelet
  • Actin
  • 90-Kda Protein
  • Gelsolin
Disciplines
  • Biology
  • Medicine

Abstract

Abstract A 90-kDa protein-actin stable complex was purified from blood platelets by a short and efficient procedure giving at the same time actin used in polymerization assays. 90-kDa protein free of actin was prepared from the complex by 8 M ureau treatment and renaturation. By its molecular mass, immunological cross-reactivity with macrophage gelsolin and its effect on G- and F-actin the 90-kDa protein appears as the platelet gelsolin.

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