Home 3-day uroflowmetry was made in 41 female patients (mean age 46 years) before and after therapy for overactive bladder (OB). The course of therapy lasting from 6 weeks to 3 months included M-cholinolytics and vascular medication. Estimation of the bladder capacity in different time of 24-h period revealed circadian deviations of urinary flow and volumes. Administration of short-term M-cholinolytics enables chronotherapy providing maximal effects within 4-6 hours, possibility to vary doses. In view of this, optimal cholinergic therapy of OB is trospium chloride which has necessary properties, high safety and wide dose range.